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The mechanism behind potential synergy involves multiple appetite-regulation pathways: GLP-1 signaling in the hypothalamus and gut, combined with naltrexone's effects on pro-opioidergic appetite signals

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BPC-157 is also named on WADA's Prohibited List under section S0 (Non-Approved Substances), the first time WADA named a specific substance by name as an example within that category (added for the 2022 List)

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