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North Carolina Department of Health and Human Services

IGF-DES Receptor Binding Specificity Competitive binding and receptor cross-linking experiments confirmed that both IGF-1 and des-(1-3)IGF-1 bind exclusively to the type 1 IGF receptor in L6 myoblasts, rat vascular smooth-muscle cells, and human lung fibroblasts with des-(1-3)IGF-1 demonstrating greater apparent potency in these assays, attributable to its low affinity for the competing 38 kDa IGFBP rather than differences in intrinsic receptor affinity

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The estimated mean percent change in body weight from baseline to week 68 was 20.4% with cagrilintidesemaglutide as compared with 3.0% with placebo (estimated difference, 17.3 percentage points