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The bottom line is straightforward

Semaglutide, inspired directly by HUMAN GLP-1, was designed to have a longer half-life (70 times) and be a more effective drug

Sources Reta-friendly recipes glp3.wiki GLP-1 RA nutrient intake study Frontiers in Nutrition Dietary intake on GLP-1/GIP agonists Research Square Nutrition interventions with GLP-1 therapies Obesity Pillars 2025 joint advisory on nutrition with GLP-1 therapy Obesity Pillars / PMC Phase 2 trial (NEJM) New England Journal of Medicine Related reading Protein Target Calculator for Retatrutide Daily protein target from weight and optional body fat % lean-mass or ABW path, formula shown, appetite-broken playbook

2003 Dec;56(6):6358