Tirzepatide is a dual agonist that combines: GLP-1 (glucagon-like peptide-1) activity GIP (glucose-dependent insulinotropic polypeptide) activity This combination creates a stronger incretin effect, improving insulin sensitivity and appetite control more effectively than GLP-1 medications alone
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these drugs should not be used in patients with a personal or family history of medullary thyroid carcinoma or MEN2 Rare cases of retinopathy progression in patients with pre-existing severe diabetic retinopathy, likely related to rapid glycemic improvement Potential drug interactions related to delayed gastric emptying, which can affect absorption of other oral medications The practical approach is dose titration
It's important to understand that GLP-1 medications come in two main types: single-use pens (like Wegovy, Trulicity, and Bydureon BCise) that are used once and discarded, and multi-dose pens (like Ozempic, Victoza, Saxenda, and Byetta) that are used multiple times until empty