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The pore has a highly hydrophobic section that could accommodate a fatty acid tail, potentially aligning the hydrolysable ester bond with the active site residues in a relatively more hydrophilic section of the pore entrance (Fig
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NICE guidance and NHS resources provide a robust framework for sustainable weight management that does not rely on investigational pharmacology
Conflicts of interest Frhbeck G received honoraria from Lilly, Novo Nordisk, Regeneron, AstraZeneca and Boehringer Ingelheim as a member of advisory boards, and honoraria for lectures as a member of the OPEN Spain Initiative
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