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Collagen is needed in order to keep the skins firmness and elasticity
18 Second, disruption of -catenin-dependent cellcell adhesion, which destabilizes adherens junctions and increases intercellular spacing, almost completely abolished propagation
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Existe tambm a relao com anormalidades microvasculares que provocam diminuio do fluxo sangneo e hipxia neural, alterao do metabolismo de cidos graxos, estresse oxidativo e diminuio de fatores de crescimento para os neurnios e clulas Schwann 32,33
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