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At the same time, new therapeutic approaches are emerging

But for manyespecially those navigating the hormonal complexities of PCOS, menopause, or insulin resistancethis perspective failed because it blatantly ignored a rather crucial reality: our biology

27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication