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Determining the appropriate dose and dosing regimen, for example, requires pharmaceutical companies to navigate a finely balanced set of variables to ensure a drug delivers the optimal effect with minimal impact on the patient

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Histologically, besides hyperpigmentation of basilar keratinocytes, lentiginous melanocytic hyperplasia may be observed in association with marked secondary epidermal rete hyperplasia, sometimes simulating the appearance of a reticulated seborrheic keratosis