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Some of the primary benefits of methylation include: DNA synthesis and repair Gene expression Neurotransmitter synthesis Hormone regulation Detoxification Immune system function Energy production Toxins and Their Impact on Methylation, Glutathione, and Antioxidant Production Toxins, including environmental pollutants, drugs, and chemicals in food, can impair the methylation pathway by interfering with the enzymes involved in the process

however, many other conducive mechanisms have been described, including the nitric oxide pathway, endothelin-induced vasoconstriction, pro-inflammatory cascades, hypoxia-inducible factor-1 (HIF-1) transcriptional modulation, oxidative stress, and apoptosis from early brain injury (EBI), among others [13,14,15]