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Tirzepatide, on the other hand, is a glucose-dependent insulinotropic polypeptide (GIP) receptor and GLP-1 receptor agonistsometimes called a dual GIP/GLP-1 receptor agonist
Notably, while virtually all recent trials specified hematocrit control or complete/partial response as the primary endpoint and time to response and adverse events as secondary endpoints none assessed efficacy in terms of reducing thrombotic risk in patients with PV or progression to myelofibrosis or leukemia
Lu J, Chen L, Liu W, Guo W
Skipping titration steps or increasing doses too quickly is the most common reason patients experience more intense side effects than necessary
