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Likewise, Chen et al ., based on a large study population (over 132,000 adults followed for almost six years) without T2D at baseline, found that NAFLD, ALT, AST, GGT, and ALP were associated with the risk of new onset T2D in both sexes with hazard ratios (HRs) of 2.08, 1.27, 1.23, 1.58, and 1.37, respectively, in men, and 2.65, 1.56, 1.18, 1.48, and 1.44, respectively, in women [33]