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When to choose tirzepatide over semaglutide for PCOS Tirzepatide may be the better choice when insulin resistance is severe and central to the PCOS presentation, when significant weight loss is needed to achieve hormonal improvement, when a patient has not responded adequately to semaglutide alone, or when the dual mechanism offers potential for fewer GI side effects

The amidotransferase reaction catalyzed by PRPP amidotransferase is also feed-back inhibited allosterically by binding ATP, ADP, and AMP at one inhibitory site and GTP, GDP, and GMP at another

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