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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]
Biomed Tech (Berl) 43 Suppl:70-1, 1998
Silvano Junior Santini, University of L'Aquila, Italy Updates Copyright 2023 Santacroce, Gentile, Soriano, Novelli, Lenti and Di Sabatino
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