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et al (2021) Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network

We found that, despite similar binding affinity, coupling of lixisenatide to cAMP signalling was reduced compared to exendin-4

Thus, researchers value GLP1-T because it offers: High stability under standard storage and handling conditions Strong GLP-1 receptor agonism, ensuring consistent receptor activation in models Extended activity compared to natural GLP-1, enabling long-duration experiments Reliable solubility in common research diluents for ease of use These qualities make GLP1-S a key peptide in studies related to obesity, diabetes, and metabolic research

Given the potential for long-term GLP-1 therapy for weight loss and diabetes, we want to avoid anything that could lead to dependence