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While B12 has very low toxicity as a water-soluble vitamin with excess typically excreted in urine, rare adverse reactions can occur
That is the fundamental compromise of any fixed blend, and understanding it is what separates informed research use from cargo-culting a protocol
J Clin Oncol 2011
Several studies have shown that mega doses of the vitamin can lead to outbreaks of acne and rosacea which is a skin condition that causes redness and pus-filled bumps on the face
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