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doi: 10.1007/s12325-019-01101-6

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They should be decoded, including but not limited to determining the best conditions and food sources for butyrate production by gut microbiota in situ , absorption of dietary and microbially produced butyrate under different physiological and pathological conditions, the regulatory mechanisms of butyrate at a cellular and systemic levels and the potential of using it as a therapeutic alternative in some obesity-associated metabolic alterations