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This stability profile is attributed to the peptide's proline-rich sequence, which confers resistance to cleavage by pepsin and other gastric proteases

This weight loss effect is generally attributed to increased urinary glucose excretion and slight reductions in body fluid volume

It is being evaluated through Eli Lilly's Phase 3 TRIUMPH program

Indeed, the European multicenter study coordinated by Graham reports that, whereas basal hyperhomocysteinemia only shows an additive effect with hypercholesterolemia, it has a synergistic effect with both hypertension and smoking on the incidence of atherosclerotic vascular disease (Graham et al, 1997)