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Its role in human physiology is multifaceted: Stimulates insulin secretion from pancreatic beta cells Suppresses glucagon release from alpha cells Slows gastric emptying, improving satiety Acts on the brain, reducing appetite and promoting satiety Unlike insulin, which has been a focus of metabolic treatment for over a century, GLP-1s therapeutic potential was not fully appreciated until the late 20th century

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Healthy weight loss should ideally preserve lean tissue while reducing fat