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At 265 lb, exposure ran 21% to 33% lower the spread reflects genuine disagreement between the two class models and the FDAs own reading of one of them, not measurement noise. On that class-based model, 1 mg in a 155 lb person can approximate the exposure produced by 1.5 mg in the 240 lb trial cohort
build in margin for storage limits
This means that the injection is given in the identified regions best suited for this type of injection that is directly administered into the muscle
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