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Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum
It neutralizes free radicals, supports detoxification, and helps regenerate other antioxidants including vitamin C and vitamin E after they've done their work
Berberine studies suggest more modest effects, though direct head-to-head comparisons are lacking
Tomkins et al., 2000
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