A truly important article that everyone should read
This article focuses on what matters most to dermatologists: which patients to consider, what to expect clinically, how to discuss GLP-1s and weight in the exam room, and how to co-manage safety and access with colleagues in primary care, endocrinology, and ophthalmology
Still, this new work with cryo-EM technology may serve us as a reminder, albeit indirect, that not paying full attention to adverse effects of undetected and unmanaged hyperinsulinism, the first dimension of insulin dysregulation, leaves much to be desired
This objectively quantifies changes in visceral fat, subcutaneous fat, and lean mass, allowing researchers to evaluate whether the combination is producing the hypothesized benefits (preferential visceral fat loss with muscle preservation)