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If this inhibition translates in vivo, isotretinoin plasma concentrations could rise beyond the intended therapeutic range, increasing exposure to both the parent compound and its hepatotoxic metabolites

Although similar mechanisms may be involved in Se discharge from the brain, i.e., involving SELENOP and minor low molecular weight Se-metabolites, there are no relevant studies supporting this notion, to the best of the authors knowledge

The cargo hold of an airplane can experience extreme temperature fluctuations and pressure changes that could damage the pens or vials