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Unlike most abundantly synthesized molecules, such as ATP or DNA, the production of GSH is controlled at the enzymatic level by a holoenzyme, glutamate-cysteine ligase (GCL), a heterodimer composed of a catalytic subunit (GCLC), and a modifier subunit (GCLM)

Another clinical trial reported that combining TRE with GLP-1 medications, such as semaglutide, amplified weight loss effects by controlling hunger and reducing calorie intake

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