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Circulating levels decline with agefrom ~200 ng/mL at age 20 to ~80 ng/mL by age 60correlating with decreased regenerative capacity
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Vzquez-Fresno R, Rosana ARR, Sajed T, Onookome-Okome T, Wishart NA, Wishart DS
A study on effects of positive and negative allosteric modulators (PAM and NAM, respectively) of 5 GABAA receptors has shown that 10-day treatment of NAM reduces the level of anxiety in six-month-old 5xFAD male mice, but without an effect in female transgenic mice, suggesting sex-specific changes in GABA signaling (Aranelovi et al., 2021)
