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Description

Toll-like receptor-mediated IRE1 activation as a therapeutic target for inflammatory arthritis

The stereoisomer GN of Sch B can ameliorate ERS-induced hepatic steatosis (142), reduce the expression of ERS markers and inflammatory genesincluding glucose regulatory protein 78 (GRP78), C/EBP-homologous protein, and X-box binding protein-1 (XBP-1)and reduce the accumulation of TGs