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Emerging data also suggest potential benefits in slowing the progression of vascular inflammation and stabilizing plaques, which may partially explain the observed reductions in ischemic events
S.BrunnstromA.PelcmanB.et al (2017)
Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]
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