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On this basis, this review systematically summarizes the pharmacokinetic evidence and biological basis of long-term in vivo accumulation of platinum-based chemotherapeutic agents, elaborates on the mechanisms of organ toxicity mediated by platinum accumulation, clarifies the core association between insufficient platinum accumulation in tumor cells and chemoresistance, and finally concludes the key challenges and future research directions in this field, aiming to provide a theoretical basis for individualized adjustment of clinical chemotherapy regimens, early screening and intervention of long-term toxicity caused by platinum accumulation, and long-term health management of cancer survivors

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The ideal daily dose of oral glutathione typically ranges from 250 to 1,000 mg, with many effective supplements offering 250 to 500 mg per serving