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Biochemically, GLP-1 medications are peptides
The UNC School of Medicine lab of Zoe McElligott, PhD, and colleagues found that the animal tranquilizer xylazine activates opioid receptors in the brain, suggesting a reason why the treatment naloxone triggers a more severe withdrawal response when given to individuals on fentanyl/xylazine and suffering from respiratory depression
These highlighted how important psychological and emotional support is for patients living with obesity, and that patients require a holistic approach to care in order to make lasting behavioural challenges (figure 2)
Consequently, this may lead to a gradual lightening of the skin tone
