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In addition, the levels of growth hormone (GH), another anabolic hormone involved in muscle mass through the PI3K-AKT/PKB-mTOR pathway, is reduced with aging and obesity and participates in the pathogenesis of sarcopenic obesity ( Growth differentiation factor 15 (GDF15) has been implicated in aging, inflammation, mitochondrial dysfunction, cachexia, and sarcopenia ( Figure 1 )

If the phase 2b trial goes well, its possible the company could trial the combination of bimagrumab and tirzepatide or another one of the GLP-1 agonists in its pipeline

Work with a prescriber familiar with peptide pharmacology if considering off-label use