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All currently marketed anti-diabetic drugs targeting DPP-4 block substrate binding by making hydrogen bonds with the anchoring residues Glu205/Glu206 and occupying the S1 hydrophobic pocket (Figure 7)

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5 Future research outlook Over a relatively short period, obesity is a significant public health problem rising

Case reports CASE 1 On august 2005, a 7-year-old Caucasian Brazilian boy presented to the Oral Diagnosis Clinic (Orocentro), School of Dentistry, State University of Campinas, Piracicaba, So Paulo, Brazil, for evaluation and management of a pigmented macule discovered during routine dental treatment on the attached gingiva of the partial erupted mandibular left permanent canine