7,8 When the multiple risk factor group (ie, those without an established cardiovascular event) was looked at on its own and meta-analysis undertaken with a similar group from CANVAS, the combined end point of cardiovascular death and hospitalisation for heart failure showed a 16% reduction (HR = 0.84, 95% CI 0.69 to 1.01), although this did not quite achieve statistical significance (p=0.06, Figure 4)
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Abbreviations ATO: Atorvastatin Bcl-2: B-Cell Lymphoma 2 CAT: Catalase CoQ10: Coenzyme Q10 Co-tx: Co-Treatment CYP3A4: Cytochrome P450 3A4 D bil: Direct Bilirubin DILI: Drug-Induced Liver Injury MDA: Malondialdehyde Post-tx: Post-Treatment PXR: Pregnane X Receptor RNS: Reactive Nitrogen Species ROS: Reactive Oxygen Species SOD: Superoxide Dismutase T bil: Total Bilirubin mPTP: Mitochondrial Permeability Transition Pore References Saleh AK, El-Masry TA, El-Kadem AH, Ashour NA, El-Mahdy NA
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