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GLP-1 expression was downregulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expression of lipolysis and autophagy-related genes and proteins were also inhibited, such as adipose triacylglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and hepatic lipase deficiency gene (LIPC)

The new study, published in the journal Obesity , analyzed health records for 207 adults who previously had bariatric surgery and were then treated for obesity at UTSWs Weight Wellness Program between 2015 and 2021