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Carnitine depletion can also result in intracellular accumulation of toxic acyl-CoA, resulting in impairment in several enzymatic processes (-ketoacid oxidation and gluconeogenesis, among others)
Retatrutide targets three distinct receptor pathways (GLP-1, GIP, and glucagon) to suppress appetite, enhance fat metabolism, and promote significant weight loss averaging 24% over 48 weeks
J Neurosci 34:70277042
mTOR links incretin signaling to HIF induction in pancreatic beta cells
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