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Dosing every 23 weeks is appropriate only during maintenance phases after initial weight loss has plateaued

the vialed powder can also be reconstituted for subcutaneous use

GLP-1-based therapies and resmetirom operate through distinct and potentially complementary mechanisms: while resmetirom exerts direct hepatic effects by activating THR- to enhance mitochondrial function, reduce hepatic lipogenesis, and promote lipid oxidation specifically in hepatocytes, GLP-1 RAs and multi-agonists address the upstream metabolic drivers of MASLD including insulin resistance, obesity, and systemic inflammation

Dose-dependent increases in heart rate were observed, peaking at 24 weeks and declining thereafter