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The RAPID-OLE study, published in The Lancet in 2015, confirmed the efficacy of augmentation therapy on lung density, measured by computed tomography (CT densitometry), over a total observation and treatment period of four years

This is a genuine gap in the safety dossier, not a minor technicality

The varied success of anti-inflammatory agents suggests that targeting specific inflammatory pathways (like IL-1 or IL-6) or using agents with broad but relevant mechanisms (like colchicine affecting inflammasomes and neutrophil function) may be more effective than general immunosuppression (methotrexate) or targeting single enzymes (darapladib)