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These medications work by affecting appetite, blood sugar, and gastric emptying, which is central to the stomach paralysis allegations in the GLP-1 litigation
First discovered in distal intestinal peptide YY (PYY)-containing EECs 95 , neuropod cells in the intestine can sense sugars and transduce a signal to the brainstem within milliseconds via a single synapse 96
This is the initial clinical trial investigating the switch from injectable incretin-based therapy to an oral OMM for the maintenance of body weight reduction, and as a result, the study evaluated various endpoints, acknowledging that the clinical relevance of these endpoints may not be appreciated until trial completion
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