While liposomal glutathione is generally recognized as safe and well-tolerated, there are important interactions to consider
A Phase III, Randomised, Double Blind, Placebo Controlled, Parallel Group Study, to Evaluate the Safety and Efficacy of Subcutaneous Implants of Afamelanotide (16 mg) in Patients Suffering From Polymorphic Light Eruption (PLE) (Report)
More serious risks include pancreatitis, gallbladder disease, acute kidney injury, and a boxed warning for thyroid C-cell tumors (with a contraindication in patients with personal/family history of MTC or MEN2)
Specifically, the use of chemotherapy drugs resulted in elevated levels of ALT and AST, and an increase in the severity of side effects such as nausea and vomiting, contributing to high GSH intake