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Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval
Diagnostic blood samples should usually be taken before replacement starts because treatment can affect results
Similar to the findings of other studies in the STEP trial program 7,27 , exploratory outcomes showed that in the semaglutide group 80% of participants with prediabetes at baseline reverted to normoglycemia by the end of the trial (compared with 37% of those receiving placebo), while 99% of participants with normoglycemia at baseline maintained normoglycemia at the end of the trial (compared with 86% with placebo)
NAD plays a central role in cellular repair and mitochondrial function
