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Sitagliptin was not mutagenic or clastogenic with or without metabolic activation in the Ames bacterial mutagenicity assay, a Chinese hamster ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay
Taking breaks is generally not recommended because restarting requires gradual dose escalation, and intermittent use may reduce effectiveness or increase side effects
The CDC reports that most U.S
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