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Interestingly, BCNU pretreatment sensitized hepatocytes to TNF-induced cell death (Fig

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Serine from SSP can directly bind to pyruvate kinase M2 (PKM2), the last rate-limiting enzyme of glycolysis, and promote the allosteric activation of PKM2 for the positive feedback of continuously activated glycolysis and serine synthesis (Chaneton et al., 2012)