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Mitochondria are unique organelles, coordinating metabolic and apoptotic crosstalk to tightly regulate cell survival 10

Oral administration demonstrates activity in gastrointestinal conditions despite lower systemic bioavailability, as direct mucosal exposure may contribute to therapeutic effects

The main mechanism of ferroptosis Inhibiting the cysteine-glutamate transporter system Xc can induce ferroptosis System Xc is a sodium independent antiporter that export intracellular glutamate and import extracellular cystine across the membrane in a ratio of 1:1 to synthesize glutathione in cells [19]