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Pregnant or breastfeeding patients should discuss with their obstetric provider before starting this injection, and ensure all healthcare team members are aware, so that vitamin levels and any pregnancy-related effects can be monitored appropriately

and people with conditions that cause nutrient malabsorption and/or gastrointestinal blood loss (such as celiac disease, ulcerative colitis, and Crohn's disease)

rapid IV push of concentrated B vitamins can cause dizziness or flushing