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Biochem Biophys Res Commun 318(1):8894

Though most menopause symptoms (e.g., hot flashes and mood swings) are attributed to the hormonal fluctuations of the menopause transition or perimenopause phase, women in postmenopause can also experience unpleasant health effects from the resulting hormonal changes, particularly because of lower estrogen levels in the body.32 How do female hormone balance supplements work

Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]