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Many of the wellness benefits attributed to ipamorelin are extrapolated from its GH-releasing mechanism and from broader GH research rather than from ipamorelin-specific trials

Prevalence of multiple chronic conditions among US adults: estimates from the National Health Interview Survey, 2010

Figure 2 More recently, a multiple hits theory has been proposed, with the addition of other pathogenic factors in NAFLD development: low-grade chronic inflammation, genetic and epigenetic mutations, and intestinal microbiota

Combing this with other medications that also increase serotonin, such as antidepressants like selective serotonin reuptake inhibitors, or SSRIs, could cause serotonin syndrome