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manufacturing capacity for GLP-1 drugs such as Wegovy and Ozempic, underscoring the overwhelming demand and global supply challenges in addressing obesity at scale
GLP-1Rs are expressed primarily on GABAergic cells in the VTA Next, we showed that a behaviorally relevant dose of exendin-4 that reduced cocaine seeking 8,18 crossed the blood brain barrier, bound putative GLP-1Rs on neurons in the VTA, and induced c-Fos expression in these neurons (Suppl
K., Palle, K
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This translated into real outcomes in the SELECT trial , where semaglutide reduced heart attacks, strokes and cardiovascular deaths by around 20% in people with established heart disease without diabetes
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