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In practical terms, they act as chemical messengers: they bind to receptors on cells, interact directly with proteins, or prompt the body to release a specific hormone, then let that hormone carry out the actual work

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However, cholecystectomy is a procedure performed with high frequency in patients undergoing metabolic surgery, both before and after surgery [9]

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For obesity without binge eating, the primary dysfunction appears to be impaired GLP-1 action, characterized by reduced satiety signaling and relatively rapid gastric emptying

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