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Key Benefits Observed: Significant weight loss: substantial and sustained reductions in body weight have been observed Appetite Suppression: satiety signals have been observed to spike, leading to vastly reduced caloric consumption
Eating schedule : Finishing meals at least 34 hours before lying down allows more time for gastric emptying and reduces nocturnal reflux
Adherence to the trial protocol was maintained where possible during the COVID-19 pandemic (see ESM Appendix 3 for further details)
They can also suppress appetite even further, making it harder to meet protein and nutrient needs a challenge already posed by these medications
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