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However, due to the increased toxicity of the current environment, this recycling process can become overwhelmed, leading to a higher toxic load and an increased risk of disease

A possible reason for the consumption of GSH during oxidative stress is its conversion into oxidized form, which can be conjugated with protein thiol groups to form mixed disulphides (PSSG), via a process called protein-S-thiolation 59

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J Biol Chem 278:4686946877 Conklin PL, Foyer CH, Hancock RD, Ishikawa T, Smirnoff N (2024) Ascorbate acid metabolism and functions