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Adequate calorie intake very low calorie intake amplifies lean mass loss
Additionally, the appetite suppression that makes these medications effective for weight management may inadvertently reduce overall fluid intake, as patients often consume less food and beverages throughout the day
When osteoclast activity exceeds osteoblast (bone-building) activity the net result is loss of bone density.' Research supports this, as one trial found that taking semaglutide (one form of GLP-1) was associated with lower bone density and an increased rate of bone breakdown
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