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The use of targeted nanocarriers solves the problems of both insufficient brain penetration of hydrophilic therapeutic molecules and high treatment doses inducing side-effects at the periphery [21, 26]
They are believed to increase the extracellular availability of the neurotransmitter serotonin by limiting its reabsorption into the presynaptic cell, so that serotonin levels are increased in the synaptic cleft and available for binding to postsynaptic receptors
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Association between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and cancer riska meta-analysis
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